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Broad Sarbecovirus Neutralizing Antibodies Obtained by Computational Design and Synthetic Library Screening

27 Jun 2023

Abstract excerpt

includes human SARS-CoV, SARS-CoV-2, and hundreds of genetically related bat viruses. The continuous evolution of SARS-CoV-2 has led to the striking evasion of neutralizing antibody (NAb) drugs and convalescent plasma. Antibodies with broad activity across sarbecoviruses would be helpful to combat current SARS-CoV-2 mutations and longer term animal virus spillovers. The study of pan-sarbecovirus NAbs described...

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PMID: 37367229
DOI: 10.1128/jvi.00610-23

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