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Article

Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Apr 2011

Sun Zhengrong, Ren Gaowei, Cui Xin, Zhou Weiqiang, Liu Chao, Ruan Qiang

Abstract excerpt

INTRODUCTION: High-risk human papillomaviruses (HPVs) play a cardinal role in the etiology of cervical cancer. The most prevalent type, HPV-16, shows intratypic sequence variants that are known to differ in oncogenic potential and geographic distribution. Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV-16 are associated with risk of viral persistence and progression. METHODS: This study was...

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PMID: 21436703
DOI: 10.1097/IGC.0b013e3182112023

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