Article
In-depth characterization of intratumoral heterogeneity in refractory B-cell non-Hodgkin lymphoma through the lens of a Research Autopsy Program.
Haematologica - 1 Jan 2023
Isaev Keren, Liu Ting, Bakhtiari Mehran, Tong Kit, Goswami Rashmi, Lam Bernard, Lungu Ilinca, Krzyzanowski Paul M, Oza Amit, Dhani Neesha, Prica Anca, Crump Michael, Kridel Robert
Abstract excerpt
Intratumoral heterogeneity (ITH) provides the substrate for tumor evolution and treatment resistance, yet is remarkably understudied in lymphoma, due to the often limited amount of tissue that gets sampled during the routine diagnostic process, generally from a single nodal or extranodal site. Furthermore, the trajectory of how lymphoma, and especially non-Hodgkin lymphoma, spreads throughout the human body...
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