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Article

Severity Level and Duration of Energy Deficit in Mice Affect Bone Phenotype and Bone Marrow Stromal Cell Differentiation Capacity.

Frontiers in endocrinology - 1 Jan 2022

Avilkina Viktorija, Leterme Damien, Falgayrac Guillaume, Delattre Jérôme, Miellot Flore, Gauthier Véronique, Chauveau Christophe, Ghali Mhenni Olfa

Abstract excerpt

Anorexia nervosa is known to induce changes in bone parameters and an increase in bone marrow adiposity (BMA) that depend on the duration and seriousness of the disease. Previous studies have found that bone loss is associated with BMA accumulation. Sirtuin of type 1 (Sirt1), a histone deacetylase that is partly regulated by energy balance, was shown to have pro-osteoblastogenic and anti-adipogenic effects. To...

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Identifiers

PMID: 35733777
DOI: 10.3389/fendo.2022.880503
PMCID: PMC9207532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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