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The Multifaceted Roles of Bone Marrow Adipocytes in Bone and Hematopoietic Homeostasis

13 Jun 2023

Abstract excerpt

Bone marrow adipose tissue (BMAT) makes up a significant portion of the marrow space, ranging from 50% to 70%, in healthy adults. It expands with aging, obesity, anorexia nervosa, and irradiation, which are conditions associated with skeletal complications or hematopoietic disorders. Therefore, BMAT has been viewed as a negative component of the bone marrow niche for decades, although the mechanisms and causative...

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PMID: 37315208
DOI: 10.1210/clinem/dgad355

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