Article
Mechanisms of Transcranial Doppler Ultrasound phenotypes in paediatric cerebral malaria remain elusive.
Malaria journal - 21 Jun 2022
O'Brien Nicole F, Fonseca Yudy, Johnson Hunter C, Postels Douglas, Birbeck Gretchen L, Chimalizeni Yamikani, Seydel Karl B, Bernard Gushu Montfort, Phiri Tusekile, June Sylvester, Chetcuti Karen, Vidal Lorenna, Goyal Manu S, Taylor Terrie E
Abstract excerpt
BACKGROUND: Cerebral malaria (CM) results in significant paediatric death and neurodisability in sub-Saharan Africa. Several different alterations to typical Transcranial Doppler Ultrasound (TCD) flow velocities and waveforms in CM have been described, but mechanistic contributors to these abnormalities are unknown. If identified, targeted, TCD-guided adjunctive therapy in CM may improve outcomes. METHODS: This...
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