Article
Identification of a Novel Clinical Phenotype of Severe Malaria using a Network-Based Clustering Approach.
Scientific reports - 27 Aug 2018
Cominetti Ornella, Smith David, Hoffman Fred, Jallow Muminatou, Thézénas Marie L, Huang Honglei, Kwiatkowski Dominic, Maini Philip K, Casals-Pascual Climent
Abstract excerpt
The parasite Plasmodium falciparum is the main cause of severe malaria (SM). Despite treatment with antimalarial drugs, more than 400,000 deaths are reported every year, mainly in African children. The diversity of clinical presentations associated with SM highlights important differences in disease pathogenesis that often require specific therapeutic options. The clinical heterogeneity of SM is largely...
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