Article
Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania.
British journal of haematology - 1 Jun 2014
Cox Sharon E, Makani Julie, Soka Deogratias, L'Esperence Veline S, Kija Edward, Dominguez-Salas Paula, Newton Charles R J, Birch Anthony A, Prentice Andrew M, Kirkham Fenella J
Abstract excerpt
Transcranial Doppler ultrasonography measures cerebral blood flow velocity (CBFv) of basal intracranial vessels and is used clinically to detect stroke risk in children with sickle cell anaemia (SCA). Co-inheritance in SCA of alpha-thalassaemia and glucose-6-phosphate dehydrogenase (G6PD) polymorphisms is reported to associate with high CBFv and/or risk of stroke. The effect of a common functional polymorphism of...
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