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Article

Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival.

Oncotarget - 1 Jan 2022

Ulanja Mark B, Moody Alastair E, Beutler Bryce D, Antwi-Amoabeng Daniel, Rahman Ganiyu A, Alese Olatunji B

Abstract excerpt

OBJECTIVES: Early-onset pancreatic cancer (EOPC) - defined as pancreatic cancer diagnosed before the age of 50 years - is associated with a poor prognosis as compared to later-onset pancreatic cancer (LOPC). Emerging evidence suggests that EOPC may exhibit a genetic signature and tumor biology that is distinct from that of LOPC. We review genetic mutations that are more prevalent in EOPC relative to LOPC and...

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Identifiers

PMID: 35720978
DOI: 10.18632/oncotarget.28242
PMCID: PMC9200435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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