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Clinical and Molecular Characteristics of Patients With Young-Onset and Average-Onset Pancreatic Adenocarcinoma.

JCO precision oncology - 1 Jan 2026

Gamboa Adriana C, Lewis Kever A, Prakash Laura R, Li Zhouxuan, Qiao Wei, Zhao Dan, Hurd Mark W, Yousef Mahmoud, Ikoma Naruhiko, Kim Michael P, Lee Jeffrey E, Maxwell Jessica E, Tzeng Ching-Wei D, Katz Matthew H G, Snyder Rebecca A

Abstract excerpt

PURPOSE: The incidence of young-onset pancreatic cancer (YO-PC) has risen over the past two decades, yet its molecular characteristics and long-term outcomes remain poorly defined. METHODS: We retrospectively evaluated patients with PC treated at a tertiary referral center from 2016 to 2022 who had available molecular data. Patients were classified as YO-PC (≤50 years) or average-onset PC (AO-PC, >50 years). A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41538760
DOI: 10.1200/PO-25-00703
PMCID: PMC12810767

Genes

PC
KRAS
CDKN2A
SMAD4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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