Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of hepatic fibrosis markers in the serum of chronic hepatitis B patients according to basal core promoter/precore mutants.

Scientific reports - 17 Jun 2022

Lefeuvre Caroline, Roux Marine, Blanchard Simon, Le Guillou-Guillemette Hélène, Boursier Jérôme, Lunel-Fabiani Françoise, Jeannin Pascale, Pivert Adeline, Ducancelle Alexandra

Abstract excerpt

The A1762T/G1764A double mutant in the basal core promoter (BCP) region of the hepatitis B virus (HBV) is associated with severe hepatic lesions while the G1899A mutation with the double mutant is associated with a significant reduction in the risk of severe fibrosis. This study aims to measure a number of markers in the serum of patients with chronic HBV infection and to assess relationships between these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Becaplermin
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Liver Cirrhosis

Share to Tissue Inhibitor of Metalloproteinase-1

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 35715541
DOI: 10.1038/s41598-022-14285-9
PMCID: PMC9205978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of hepatic fibrosis markers in the serum of chronic hepatitis B patients according to basal core promoter/precore mutants.PMID 35715541Read ↗

Different precore/core mutations of hepatitis B interact with, limit, or favor liver fibrosis severity.Semantic proximity Read ↗

Development of a fibrosis index including hepatitis B virus basal core promoter A1762T mutation for pretherapeutic evaluation.Semantic proximity Read ↗

Mutations in basal core promoter is associated with significant fibrosis in both HBeAg positive and negative treatment-naïve chronic hepatitis B.Semantic proximity Read ↗

The Synergistic Effect of TNFα -308 G/A and TGFβ1 -509 C/T Polymorphisms on Hepatic Fibrosis Progression in Hepatitis C Virus Genotype 4 Patients.Semantic proximity Read ↗

Precore/core promoter mutations and hepatitis B virus genotype in hepatitis B and C dually infected patients treated with interferon-based therapy.Semantic proximity Read ↗

Impacts of the Percentage of Basal Core Promoter Mutation on the Progression of Liver Fibrosis After Hepatitis B e Antigen Seroconversion.Semantic proximity Read ↗

Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers.Semantic proximity Read ↗

Pre-core/basal-core promoter and reverse transcriptase mutations in chronic HBV infected-patients.Semantic proximity Read ↗

Precore/Core promoter variants to predict significant fibrosis in both HBeAg positive and negative chronic hepatitis B.Semantic proximity Read ↗

Precore/core promoter mutations and genotypes of hepatitis B virus in chronic hepatitis B patients with fulminant or subfulminant hepatitis.Semantic proximity Read ↗

Effect of IL-12B, IL-2, TGF-β1, and IL-4 polymorphism and expression on hepatitis B progression.Semantic proximity Read ↗

The TGFB1 -509C/T polymorphism and elevated TGF-β1 levels are associated with chronic hepatitis C and cirrhosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.