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The TGFB1 -509C/T polymorphism and elevated TGF-β1 levels are associated with chronic hepatitis C and cirrhosis.

Immunobiology - 1 Sept 2020

de Brito William Botelho, Queiroz Maria Alice Freitas, da Silva Graça Amoras Ednelza, Lima Sandra Souza, da Silva Conde Simone Regina Souza, Dos Santos Eduardo José Melo, Cayres-Vallinoto Izaura Maria Vieira, Ishak Ricardo, Vallinoto Antonio Carlos Rosário

Abstract excerpt

The IFN-γ and TGF-β1 cytokines perform antagonistic activities in the immune response, and polymorphisms in these genes may induce changes in their plasma levels and influence the course of chronic Hepacivirus C (HCV) infection. The present study evaluated the IFNG +874A/T and TGFB1 -509 C/T polymorphisms in 99 samples from patients with chronic hepatitis C and in 300 samples from healthy donors, and the present...

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PMID: 32962821
DOI: 10.1016/j.imbio.2020.152002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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