Article
Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT.
Communications biology - 16 Jun 2022
Moksnes Marta R, Graham Sarah E, Wu Kuan-Han, Hansen Ailin Falkmo, Gagliano Taliun Sarah A, Zhou Wei, Thorstensen Ketil, Fritsche Lars G, Gill Dipender, Mason Amy, Cucca Francesco, Schlessinger David, Abecasis Gonçalo R, Burgess Stephen, Åsvold Bjørn Olav, Nielsen Jonas B, Hveem Kristian, Willer Cristen J, Brumpton Ben M
Abstract excerpt
Iron is essential for many biological processes, but iron levels must be tightly regulated to avoid harmful effects of both iron deficiency and overload. Here, we perform genome-wide association studies on four iron-related biomarkers (serum iron, serum ferritin, transferrin saturation, total iron-binding capacity) in the Trøndelag Health Study (HUNT), the Michigan Genomics Initiative (MGI), and the SardiNIA...
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