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Article

African genetic ancestry is associated with lower frequency of PNPLA3 G allele in non-alcoholic fatty liver in an admixed population.

Annals of hepatology - 1 Jan 2000

Cavalcante Lourianne Nascimento, Porto Jun, Mazo Daniel, Longatto-Filho Adhemar, Stefano José Tadeu, Lyra Andre Castro, Carrilho Flair Jose, Reis Rui Manuel, Alves Venâncio A F, Sanyal Arun J, Oliveira Claudia P

Abstract excerpt

INTRODUCTION AND OBJECTIVES: PNPLA3 (rs738409) and TM6SF2 (rs58542926) variants, interindividual and ethnic differences may be risk factors for non-alcoholic fatty liver disease (NAFLD). The PNPLA3 G allele is associated with worse NAFLD evolution in Hispanics and Caucasians. TM6SF2 is associated with hypertriglyceridemia, NAFLD, and cardiovascular disease. We aimed to evaluate the association between genetic...

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PMID: 35710086
DOI: 10.1016/j.aohep.2022.100728

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