Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers.

doi:10.1038/s10038-018-0420-4

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers.

Journal of human genetics - 1 May 2018

Krawczyk Marcin, Bantel Heike, Rau Monika, Schattenberg Jörn M, Grünhage Frank, Pathil Anita, Demir Münevver, Kluwe Johannes, Boettler Tobias, Weber Susanne N, Geier Andreas, Lammert Frank

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) is frequent among obese individuals with metabolic syndrome. Variants PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7 rs641738 are associated with higher liver fat contents. Here we analyzed 63 biopsied non-obese, non-diabetic patients with NAFLD (39 men, age: 20-72 years) recruited within the German NAFLD CSG program. The frequencies of the PNPLA3, TM6SF2 and MBOAT7...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biopsy

Share to Genetic Association Studies

Share to Germany

Share to Liver Function Tests

Share to Non-alcoholic Fatty Liver Disease

Share to Severity of Illness Index

Share to Tertiary Care Centers

Source

Open in PubMed

Identifiers

PMID: 29483677
DOI: 10.1038/s10038-018-0420-4

Genes

PNPLA3
MBOAT7

Variants

rs641738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers.PMID 29483677Read ↗

Genetic Contribution to Non-alcoholic Fatty Liver Disease and Prognostic Implications.Semantic proximity Read ↗

Association of genetic variations with NAFLD in lean individuals.Semantic proximity Read ↗

Genetic and metabolic aspects of non-alcoholic fatty liver disease (NAFLD) pathogenicitySemantic proximity Read ↗

Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review.Semantic proximity Read ↗

Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study.Semantic proximity Read ↗

Update on NAFLD genetics: From new variants to the clinic.Semantic proximity Read ↗

Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children.Semantic proximity Read ↗

Association of Genetic Variations in Lean Adults with Nonalcoholic Fatty Liver Disease in Asian PopulationsSemantic proximity Read ↗

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.Semantic proximity Read ↗

Genetics of nonalcoholic fatty liver disease.Semantic proximity Read ↗

Metabolic effects of risk alleles in <i>PNPLA3, TM6SF2, GCKR</i> and <i>LYPLAL1</i> inform about heterogeneity of non-alcoholic fatty liver diseaseSemantic proximity Read ↗

Genetic risk of fatty liver disease and mortality in the general population: A Mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.