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Phenotype Identification of HeLa Cells Knockout CDK6 Gene Based on Label-Free Raman Imaging.

Analytical chemistry - 28 Jun 2022

Xu Ying, Hou Xiaoli, Zhu Qiaoqiao, Mao Shijie, Ren Jie, Lin Jidong, Xu Ning

Abstract excerpt

Identifying cell phenotypes is essential for understanding the function of biological macromolecules and molecular biology. We developed a noninvasive, label-free, single-cell Raman imaging analysis platform to distinguish between the cell phenotypes of the HeLa cell wild type (WT) and cyclin-dependent kinase 6 (CDK6) gene knockout (KO) type. Via large-scale Raman spectral and imaging analysis, two phenotypes of...

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PMID: 35704426
DOI: 10.1021/acs.analchem.2c00188

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