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Article

Colorectal Liver Micrometastases: Association with RAS/TP53 Co-Mutation and Prognosis after Surgery.

Journal of the American College of Surgeons - 1 Jul 2022

Chun Yun Shin, Passot Guillaume, Nishioka Yujiro, Katkhuda Riham, Arvide Elsa M, Benzerdjeb Nazim, Lopez Jonathan, Kopetz Scott E, Maru Dipen M, Vauthey Jean-Nicolas

Abstract excerpt

BACKGROUND: Micrometastases, defined as microscopic cancer cells spatially separated from the macroscopically evident metastasis, are identified in 24% to 56% of resected colorectal liver metastases (CLMs). Somatic gene mutations have emerged as independent prognostic factors in CLM. This study aimed to determine the prognostic impact and risk factors for the presence of micrometastases, including somatic gene...

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Identifiers

PMID: 35703957
DOI: 10.1097/XCS.0000000000000223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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