Article
Gene-gene interactions between DRD3, MRP4 and CYP2B6 polymorphisms and its influence on the pharmacokinetic parameters of efavirenz in HIV infected patients.
Drug metabolism and pharmacokinetics - 1 Oct 2016
Sánchez-Martín Almudena, Cabrera Figueroa Salvador, Cruz Raquel, Porras-Hurtado Liliana, Calvo-Boyero Fernando, Rasool Mahmood, Domínguez-Gil Hurlé Alfonso, Carracedo Angel
Abstract excerpt
Genetic factors have a significant impact on the PK variability of EFV, much higher than other non-genetic factors, such as demography. In this work we have performed a comprehensive PG analysis of genes encoding the major metabolizing enzymes and transporters of EFV, establishing a clear relationship between the PK parameters and genetic factors, which explain 50% of the variability in EFV PK parameters. The...
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