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Article

miR-146a, miR-196a2, miR-499, and miR-149 linked with susceptibility to acute lymphoblastic leukemia: A case-control study in Tunisia.

Gene - 5 Aug 2022

Dhiflaoui Amani, Mahjoub Sana, Chayeb Vera, Achour Bechir, Chouchen Saoussen, Abdennebi Hassen Ben, Mahjoub Touhami, Almawi Wassim Y

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) are promising biomarkers of hematological malignancies, including acute lymphoblastic leukaemia (ALL). Recent studies revealed that miRNA single nucleotide polymorphisms (miR-SNP) modulate cancer risk by regulating various signaling pathways. However, their association with altered risk of ALL yielded inconsistent results. OBJECTIVE: This study aims to investigate the association of...

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PMID: 35690283
DOI: 10.1016/j.gene.2022.146648

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