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Article

Genome-wide hierarchical mixed model association analysis.

Briefings in bioinformatics - 5 Nov 2021

Hao Zhiyu, Gao Jin, Song Yuxin, Yang Runqing, Liu Di

Abstract excerpt

In genome-wide mixed model association analysis, we stratified the genomic mixed model into two hierarchies to estimate genomic breeding values (GBVs) using the genomic best linear unbiased prediction and statistically infer the association of GBVs with each SNP using the generalized least square. The hierarchical mixed model (Hi-LMM) can correct confounders effectively with polygenic effects as residuals for...

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Identifiers

PMID: 34368830
DOI: 10.1093/bib/bbab306
PMCID: PMC8575042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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