Article
Phenotype, Function, and Clinical Significance of CD26+ and CD161+Tregs in Splenic Marginal Zone Lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Oct 2022
Tang Xinyi, Yang Zhi-Zhang, Kim Hyo Jin, Anagnostou Theodora, Yu Yue, Wu Xiaosheng, Chen Jun, Krull Jordan E, Wenzl Kerstin, Mondello Patrizia, Bhardwaj Vaishali, Wang Junwen, Novak Anne J, Ansell Stephen M
Abstract excerpt
PURPOSE: Regulatory T-cells (Treg) are essential to Tregs homeostasis and modulate the antitumor immune response in patients with lymphoma. However, the biology and prognostic impact of Tregs in splenic marginal zone lymphoma (SMZL) have not been studied. EXPERIMENTAL DESIGN: Biopsy specimens from 24 patients with SMZL and 12 reactive spleens (rSP) from individuals without lymphoma were analyzed by using CITE-seq...
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