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Article

Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain

15 Feb 2017

Abstract excerpt

Bcl-2 protein family is constituted by multidomain members originally identified as modulators of programmed cell death and whose expression is frequently misbalanced in cancer cells. The lead member Bcl-2 and its homologue Bcl-xL proteins are characterized by the presence of all four conserved BH domain and exert their antiapoptotic role mainly through the involvement of BH1, BH2 and BH3 homology domains, that...

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PMID: 28203756
DOI: 10.1093/carcin/bgx016

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