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Article

Perinatal Treatment with Leptin, but Not Celastrol, Protects from Metabolically Obese, Normal-Weight Phenotype in Rats.

Nutrients - 29 May 2022

Reynés Bàrbara, Cifre Margalida, Palou Andreu, Oliver Paula

Abstract excerpt

Perinatal nutrition has a well-known influence on obesity susceptibility. We previously demonstrated the protective anti-obesity effects of perinatal leptin administration. Celastrol is a natural compound acting as a leptin sensitizer with anti-obesity effects when administered in adult animals. Here, we aimed to determine if perinatal treatment with leptin, celastrol, or their combination was able to improve...

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Identifiers

PMID: 35684076
DOI: 10.3390/nu14112277
PMCID: PMC9183119

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