Article
Neonatal Overnutrition Induces Long-Lasting Hypothalamic POMC Silencing and Shapes Distinct Obesity Phenotypes According to Adult Dietary Environments.
Journal of neurochemistry - 1 Apr 2026
Fernández Pamela Rocío, Gaydou Luisa, Schumacher Rocío, Rossetti María Florencia, García Ana Paula, Morandi Gianfranco Gervasoni, Ramos Jorge Guillermo, Stoker Cora, Canesini Guillermina
Abstract excerpt
Our study aimed to analyze the individual effects of early-life overnutrition (focusing on its long-lasting impact) and adult cafeteria diet (CAF) exposure, as well as their combined effect, on hypothalamic food-intake regulation. Neonatal overfeeding was induced by a small litter model (SL, 4 pups/dam), and the control group was raised in normal litters (NL, 10 pups/dam). Male rats received control diet (CON)...
Topics
- Animals
- Overnutrition
- Pro-Opiomelanocortin
- Male
- Obesity
- Animals, Newborn
- Hypothalamus
- Rats
- Phenotype
- Rats, Wistar
- Gene Silencing
- Diet
- Female