Article
Targeting PIK3CA Actionable Mutations in the Circulome: A Proof of Concept in Metastatic Breast Cancer.
International journal of molecular sciences - 5 Jun 2022
Cardinali Barbara, De Luca Giuseppa, Tasso Roberta, Coco Simona, Garuti Anna, Buzzatti Giulia, Sciutto Andrea, Arecco Luca, Villa Federico, Carli Franca, Reverberi Daniele, Quarto Rodolfo, Dono Mariella, Del Mastro Lucia
Abstract excerpt
The study of circulating cancer-derived components (circulome) is considered the new frontier of liquid biopsy. Despite the recognized role of circulome biomarkers, their comparative molecular profiling is not yet routine. In advanced breast cancer (BC), approximately 40% of hormone-receptor-positive, HER2-negative BC cases harbor druggable PIK3CA mutations suitable for combined alpelisib/fulvestrant treatment....
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