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Article

Molecular Profiling of Endocrine Resistance in HR+/HER2-Metastatic Breast Cancer: Insights from Extracellular Vesicles-Derived DNA and ctDNA in Liquid Biopsies.

International journal of molecular sciences - 4 Dec 2024

Martínez-Rodríguez Ana, Fuentes-Antrás Jesús, Lorca Víctor, López de Sá Alfonso, Pérez-Segura Pedro, Moreno Fernando, García-Sáenz Jose Angel, García-Barberán Vanesa

Abstract excerpt

Standard treatments in hormone receptor-positive (HR+)/HER2-metastatic breast cancer (mBC) typically involve endocrine therapy (ET) combined with CDK4/6 inhibitors, yet resistance to ET remains a persistent challenge in advanced cases. A deeper knowledge of the use of liquid biopsy is crucial for the implementation of precision medicine in mBC with real-time treatment guidance. Our study assesses the prognostic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39684756
DOI: 10.3390/ijms252313045
PMCID: PMC11641624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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