PIK3CA mutation detection by circulating tumor cell sequencing guides the effective PI3K inhibitor treatment of a patient with hormone receptor-positive breast cancer transformed into triple-negative breast cancer: A case report.

Abstract excerpt

RATIONALE: Most patients with hormone receptor-positive breast cancer (BC) prefer endocrine therapy and chemotherapy. However, some HR+ BC patients often exhibit resistance to CDK4/6 inhibitors and even undergo molecular subtyping changes during disease progression. Therefore, precise detection and treatment of these patients after disease progression are crucial. PATIENT CONCERNS: In October 2021, a 51-year-old...

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