Article
Digital droplet PCR-based absolute quantification of pre-transplant NPM1 mutation burden predicts relapse in acute myeloid leukemia patients.
Annals of hematology - 1 Oct 2018
Bill Marius, Grimm Juliane, Jentzsch Madlen, Kloss Laura, Goldmann Karoline, Schulz Julia, Beinicke Stefanie, Häntschel Janine, Cross Michael, Vucinic Vladan, Pönisch Wolfram, Behre Gerhard, Franke Georg-Nikolaus, Lange Thoralf, Niederwieser Dietger, Schwind Sebastian
Abstract excerpt
Allogeneic hematopoietic stem cell transplantation is an established consolidation therapy for patients with acute myeloid leukemia. However, relapse after transplantation remains a major clinical problem resulting in poor prognosis. Thus, detection of measurable ("minimal") residual disease to identify patients at high risk of relapse is essential. A feasible method to determine measurable residual disease may...
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