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Clinical Laboratory Validation and Implementation of Quantitative, Real-Time PCR-based Detection of NPM1 Type A Mutation.

Clinical laboratory - 1 Dec 2020

Racchumi Joelle, Tam Wayne, Kluk Michael J

Abstract excerpt

BACKGROUND: NPM1 mutations have prognostic significance in acute myeloid leukemia (AML) and monitoring mutant NPM1 levels during and after therapy has been described to predict relapse and survival. Despite the published significance of this molecular biomarker, routine monitoring for mutant NPM1 levels has not been widely adopted in academic clinical laboratories. Therefore, our objective was to validate a...

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PMID: 33337831
DOI: 10.7754/Clin.Lab.2020.200104

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