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Detection of NPM1 Mutations in Acute Myeloid Leukemia by using Drop-Off Droplet Digital PCR and its Clinical Application.

Clinical laboratory - 1 Nov 2023

Jin Ye, Xu Zi-Jun, Yu Di, Xia Pei-Hui, Yao Dong-Ming, Yuan Qian, Li Ting, Xiang He-Lin, Ma Ji-Chun, Wen Xiang-Mei, Lin Jiang, Qian Jun

Abstract excerpt

BACKGROUND: Nucleophosmin 1 (NPM1) mutations, which occur in 25 - 30% of acute myeloid leukemia (AML) and 50 - 60% of AML with normal karyotype, have been identified as an important marker for stratification of prog-nosis in AML. This study aimed to establish a new quantitative polymerase chain reaction (PCR) technique, the drop-off droplet digital PCR (ddPCR), for rapid and sensitive detection of NPM1 mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37948486
DOI: 10.7754/Clin.Lab.2023.230537

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