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Histone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblasts

9 Jun 2022

Abstract excerpt

Histone deacetylases (HDACs) remove acetyl groups from lysine chains on histones and other proteins and play a crucial role in epigenetic regulation and aging. Previously, we demonstrated that HDAC4 is consistently downregulated in aged and ultraviolet (UV)-irradiated human skin in vivo. Cellular senescence is a permanent cell cycle arrest induced by various stressors. To elucidate the potential role of HDAC4 in...

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PMID: 35680564
DOI: 10.18632/aging.204118

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