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Article

Genotypic-Phenotypic Analysis, Metabolic Profiling and Clinical Correlations in Parkinson's Disease Patients from Tamil Nadu Population, India.

Journal of molecular neuroscience : MN - 1 Aug 2022

Venkatesan Dhivya, Iyer Mahalaxmi, S Robert Wilson, Narayanasamy Arul, Kamalakannan Siva, Valsala Gopalakrishnan Abilash, Vellingiri Balachandar

Abstract excerpt

Parkinson's disease (PD) is an ageing disorder caused by dopaminergic neuron depletion with age. Growing research in the field of metabolomics is expected to play a major role in PD diagnosis, prognosis and therapeutic development. In this study, we looked at how SNCA and GBA1 gene mutations, as well as metabolomic abnormalities of kynurenine and cholesterol metabolites, were linked to alpha-synuclein (α-syn) and...

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PMID: 35676593
DOI: 10.1007/s12031-022-02028-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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