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Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Human molecular genetics - 1 May 2016

Yin Xiangling, Manczak Maria, Reddy P Hemachandra

Abstract excerpt

The objective of this study was to determine the protective effects of the mitochondria-targeted molecules MitoQ and SS31 in striatal neurons that stably express mutant huntingtin (Htt) (STHDhQ111/Q111) in Huntington's disease (HD). We studied mitochondrial and synaptic activities by measuring mRNA and the protein levels of mitochondrial and synaptic genes, mitochondrial function, and ultra-structural changes in...

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PMID: 26908605
DOI: 10.1093/hmg/ddw045
PMCID: PMC4986329

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Source receipt: pubmed, retrieved 7 Sept 2026.

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