Variant to function mapping at single-cell resolution through network propagation.

doi:10.1038/s41587-022-01341-y

Article

Variant to function mapping at single-cell resolution through network propagation.

Nature biotechnology - 1 Nov 2022

Yu Fulong, Cato Liam D, Weng Chen, Liggett L Alexander, Jeon Soyoung, Xu Keren, Chiang Charleston W K, Wiemels Joseph L, Weissman Jonathan S, de Smith Adam J, Sankaran Vijay G

Abstract excerpt

Genome-wide association studies in combination with single-cell genomic atlases can provide insights into the mechanisms of disease-causal genetic variation. However, identification of disease-relevant or trait-relevant cell types, states and trajectories is often hampered by sparsity and noise, particularly in the analysis of single-cell epigenomic data. To overcome these challenges, we present SCAVENGE, a...

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Variant to function mapping at single-cell resolution through network propagation.

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