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Article

The Yak1 kinase is involved in the initiation and maintenance of hyphal growth in Candida albicans.

Molecular biology of the cell - 1 May 2008

Goyard Sophie, Knechtle Philipp, Chauvel Murielle, Mallet Adeline, Prévost Marie-Christine, Proux Caroline, Coppée Jean-Yves, Schwarz Patrick, Schwartz Patrick, Dromer Françoise, Park Hyunsook, Filler Scott G, Janbon Guilhem, d'Enfert Christophe

Abstract excerpt

Members of the dual-specificity tyrosine-phosphorylated and regulated kinase (DYRK) family perform a variety of functions in eukaryotes. We used gene disruption, targeted pharmacologic inhibition, and genome-wide transcriptional profiling to dissect the function of the Yak1 DYRK in the human fungal pathogen Candida albicans. C. albicans strains with mutant yak1 alleles showed defects in the yeast-to-hypha...

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Identifiers

PMID: 18321992
DOI: 10.1091/mbc.e07-09-0960
PMCID: PMC2366847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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