Article
[Elucidated pathogenesis and therapeutic prospects in Langerhans cell histiocytosis].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2022
Morimoto Akira, Shioda Yoko, Sakamoto Kenichi, Kudo Ko, Imamura Toshihiko, Kudo Kazuko
Abstract excerpt
Langerhans cell histiocytosis (LCH) is characterized by immature dendritic cell proliferation, which is currently classified as an inflammatory myeloid neoplasm. Clinical features and outcomes vary from spontaneously regressing isolated bone disease to fatal liver, spleen, or hematopoietic system (risk organ) involvement-positive multisystem disease. LCH cells have the only mutation in the mitogen-activated...
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