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Article

Rare HER2 L796P missense mutation promotes the growth and oncogenic signaling in breast cancer cells.

Proteomics. Clinical applications - 1 Jan 2024

Zhang Dongxue, Shi Xiaoyu, Zheng Weimin, Zhang Xian, Chen Yun

Abstract excerpt

PURPOSE: This research aimed to find potential HER2 mutations that would have an impact on breast cancer and investigate the underlying mechanism. EXPERIMENTAL DESIGN: This study first investigated 238 pairs of breast cancer and para-cancerous tissue samples from patients on the targeted next-generation sequencing (tNGS) platform. CCK-8 and clone formation assay were used to investigate whether the mutation...

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37672800
DOI: 10.1002/prca.202300061

Genes

CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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