Article
HER2 activating mutations are targets for colorectal cancer treatment.
Cancer discovery - 1 Aug 2015
Kavuri Shyam M, Jain Naveen, Galimi Francesco, Cottino Francesca, Leto Simonetta M, Migliardi Giorgia, Searleman Adam C, Shen Wei, Monsey John, Trusolino Livio, Jacobs Samuel A, Bertotti Andrea, Bose Ron
Abstract excerpt
UNLABELLED: The Cancer Genome Atlas project identified HER2 somatic mutations and gene amplification in 7% of patients with colorectal cancer. Introduction of the HER2 mutations S310F, L755S, V777L, V842I, and L866M into colon epithelial cells increased signaling pathways and anchorage-independent cell growth, indicating that they are activating mutations. Introduction of these HER2 activating mutations into...
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