Article
Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age-Related Studies in Thai Adults and Cross-Population Comparisons.
Clinical and translational science - 1 Feb 2026
Srimatimanon Thanate, Udomnilobol Udomsak, Chariyavilaskul Pajaree, Siwamogsatham Sarawut, Praditpornsilpa Kearkiat, Vorasettakarnkij Yongkasem, Petchlorlian Aisawan, Vanwong Natchaya, Piriyapongsa Jittima, Tipsombatboon Pavita, Yodsurang Varalee, Prueksaritanont Thomayant
Abstract excerpt
Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle-related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC-MS/MS assay while accounting for key SLCO1B1 variants known to affect statin exposure. We further compared our...
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