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Article

Targeting BRAF mutant metastatic colorectal cancer: clinical implications and emerging therapeutic strategies.

Targeted oncology - 1 Jun 2015

Tie Jeanne, Desai Jayesh

Abstract excerpt

Increasing knowledge of the underlying signaling pathways and molecular defects involved in colorectal cancer growth or progression enabled the discovery of several prognostic and predictive biomarkers, leading to the development of novel molecularly targeted therapies. The mitogen-activated protein kinase (MAPK) signaling pathway plays a critical role in colorectal cancer progression. Mutations in BRAF, a...

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Identifiers

PMID: 25119972
DOI: 10.1007/s11523-014-0330-0

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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