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Targeting BRAF V600E in metastatic colorectal cancer: where are we today?

15 Dec 2022

Abstract excerpt

Colorectal cancer (CRC) is the second most frequent cause of direct cancer death worldwide. The study of the molecular state of oncogenes has predictive and prognostic value in metastatic CRC (mCRC). The B-raf proto-oncogene (BRAF) gene mutation represents the 8%-12% of all mutations in mCRC. The BRAF V600E mutation, considered the most common alteration of BRAF, corresponds to a constitutive kinase with a high...

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PMID: 36819812
DOI: 10.3332/ecancer.2022.1489

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