Article
A morphometric analysis of hepatitis B subviral particles shows no correlation of filament proportion and length with clinical stage and genotype.
Journal of viral hepatitis - 1 Sept 2022
Eymieux Sébastien, Hourioux Christophe, Marlet Julien, Moreau Alain, Patient Romuald, d'Alteroche Louis, Gaudy-Graffin Catherine, Blanchard Emmanuelle, Roingeard Philippe
Abstract excerpt
It was recently suggested that the composition of circulating hepatitis B subviral particles (SVPs) could be used to differentiate the various stages in chronic hepatitis B virus (HBV) infection, with significantly lower proportions of L and M proteins in inactive carriers than in individuals with chronic hepatitis. L protein is abundant in virions and filamentous SVPs but almost absent from spherical SVPs. We,...
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