Article
Stability and morphology comparisons of self-assembled virus-like particles from wild-type and mutant human hepatitis B virus capsid proteins.
Journal of virology - 1 Dec 2003
Newman Margaret, Suk Fat-Moon, Cajimat Maria, Chua Pong Kian, Shih Chiaho
Abstract excerpt
Instead of displaying the wild-type selective export of virions containing mature genomes, human hepatitis B virus (HBV) mutant I97L, changing from an isoleucine to a leucine at amino acid 97 of HBV core antigen (HBcAg), lost the high stringency of selectivity in genome maturity during virion export. To understand the structural basis of this so-called "immature secretion" phenomenon, we compared the stability...
Topics
- Capsid
- Capsid Proteins
- Electrophoresis, Agar Gel
- Hepatitis B Core Antigens
- Hepatitis B virus
- Humans
- Microscopy, Electron
- Models, Molecular
- Mutation
- Negative Staining
- Virion
- Virus Assembly