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Increase in Mitochondrial D-Loop Region Methylation Levels in Mild Cognitive Impairment Individuals

12 May 2022

Abstract excerpt

Methylation levels of the mitochondrial displacement loop (D-loop) region have been reported to be altered in the brain and blood of Alzheimer's disease (AD) patients. Moreover, a dynamic D-loop methylation pattern was observed in the brain of transgenic AD mice along with disease progression. However, investigations on the blood cells of AD patients in the prodromal phases of the disease have not been performed...

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PMID: 35628202
DOI: 10.3390/ijms23105393

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