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Article

Polymorphisms of genes required for methionine synthesis and DNA methylation influence mitochondrial DNA methylation.

Epigenomics - 1 Jun 2020

Stoccoro Andrea, Tannorella Pierpaola, Migliore Lucia, Coppedè Fabio

Abstract excerpt

Aim: Impaired methylation of the mitochondrial DNA and particularly in the regulatory displacement loop (D-loop) region, is increasingly observed in patients with neurodegenerative disorders. The present study aims to investigate if common polymorphisms of genes required for one-carbon metabolism (MTHFR, MTRR, MTR and RFC-1) and DNA methylation reactions (DNMT1, DNMT3A and DNMT3B) influence D-loop methylation...

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Source

Identifiers

PMID: 32393056
DOI: 10.2217/epi-2020-0041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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