Article
Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes.
International journal of molecular sciences - 10 May 2022
Serth Jürgen, Peters Inga, Hill Bastian, Hübscher Tatjana, Hennenlotter Jörg, Klintschar Michael, Kuczyk Markus Antonius
Abstract excerpt
Both age-dependent and age-independent alteration of DNA methylation in human tissues are functionally associated with the development of many malignant and non-malignant human diseases. TCGA-KIRC data were biometrically analyzed to identify new loci with age-dependent DNA methylation that may contribute to tumor risk in normal kidney tissue. ANKRD34B and ZIC1 were evaluated as candidate genes by pyrosequencing...
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