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Article

A Gene Expression Signature of Acquired Chemoresistance to Cisplatin and Fluorouracil Combination Chemotherapy in Gastric Cancer Patients

18 Feb 2011

Abstract excerpt

BACKGROUND: We initiated a prospective trial to identify transcriptional alterations associated with acquired chemotherapy resistance from pre- and post-biopsy samples from the same patient and uncover potential molecular pathways involved in treatment failure to help guide therapeutic alternatives. METHODOLOGY/PRINCIPAL FINDINGS: A prospective, high-throughput transcriptional profiling study was performed using...

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PMID: 21364753
DOI: 10.1371/journal.pone.0016694

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