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Article

Molecular evolutionary process of advanced gastric cancer during sequential chemotherapy detected by circulating tumor DNA.

Journal of translational medicine - 12 Aug 2022

Xi Wenqi, Zhou Chenfei, Xu Fei, Sun Debin, Wang Shengzhou, Chen Yawei, Ji Jun, Ma Tao, Wu Junwei, Shangguan Chengfang, Zhu Zhenggang, Zhang Jun

Abstract excerpt

BACKGROUND: Efficacy of conventional sequential chemotherapy paradigm for advanced gastric cancer (AGC) patients has largely plateaued. Dynamic molecular changes during and after sequential chemotherapy have not been fully delineated. We aimed to profile the molecular evolutionary process of AGC patients during sequential chemotherapy by next generation sequencing (NGS) of plasma circulating tumor DNA (ctDNA)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35962408
DOI: 10.1186/s12967-022-03567-5
PMCID: PMC9373478

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