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Article

The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain.

Cell reports - 26 Dec 2023

Sun Yao-Hui, Kao Hillary K J, Thai Phung N, Smithers Regan, Chang Che-Wei, Pretto Dalyir, Yechikov Sergey, Oppenheimer Sarah, Bedolla Amanda, Chalker Brooke A, Ghobashy Rana, Nolta Jan A, Chan James W, Chiamvimonvat Nipavan, Lieu Deborah K

Abstract excerpt

The composite material-like extracellular matrix (ECM) in the sinoatrial node (SAN) supports the native pacemaking cardiomyocytes (PCMs). To test the roles of SAN ECM in the PCM phenotype and function, we engineered reconstructed-SAN heart tissues (rSANHTs) by recellularizing porcine SAN ECMs with hiPSC-derived PCMs. The hiPSC-PCMs in rSANHTs self-organized into clusters resembling the native SAN and displayed...

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Identifiers

PMID: 38041810
DOI: 10.1016/j.celrep.2023.113505
PMCID: PMC10790625

Genes

HCN4
TBX18
TBX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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