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Article

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface.

Frontiers in immunology - 1 Jan 2019

Papúchová Henrieta, Meissner Torsten B, Li Qin, Strominger Jack L, Tilburgs Tamara

Abstract excerpt

To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens and remain competent to respond to infections both systemically and in placental tissues. Extravillous trophoblasts (EVT) are the most invasive cells of extra-embryonic origin to invade uterine tissues and express polymorphic Human Leucocyte Antigen-C (HLA-C) of both maternal and paternal origin. Thus, HLA-C is a key...

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Identifiers

PMID: 31921098
DOI: 10.3389/fimmu.2019.02730
PMCID: PMC6913657

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